Spine & Nerve Support for Horses

Looking for spine and nerve support for your horse? We start with ImmuBiome Spine & Nerve—daily nutritional support for back comfort and healthy nerve function, built around Lion’s Mane with five more functional mushrooms, bovine colostrum, probiotics, and prebiotics. Nerve Boost pairs well when you want extra Lion’s Mane in the routine.

These supplements are for nutritional support only. They are not intended to diagnose, treat, cure, or prevent any disease, and they do not replace veterinary care. If you notice any change in your horse’s gait, coordination, or comfort, talk with your veterinarian first.

SPINE COMFORT · NERVE SUPPORT · EVERYDAY MOVEMENT

A comfortable back and a well-supported nervous system matter for every horse—from the senior in the pasture to the athlete in regular work. We start with Spine & Nerve, our most-reviewed formula, built around Lion’s Mane mushroom for daily nutritional support of spine and nerve health. Nerve Boost pairs well when you want extra Lion’s Mane alongside it. Use with good saddle fit, regular bodywork, and your veterinarian’s wellness plan.

ImmuBiome Spine & Nerve

ImmuBiome Spine & Nerve

From $69.00
ImmuBiome Nerve Boost

ImmuBiome Nerve Boost

From $69.00

Supporting a comfortable back and steady nerves

For the senior in the pasture and the athlete in regular work—everyday spine and nerve support
Spine and back comfort — close-up of a chestnut horse withers and topline in a bright barn aisle

Spine & back comfort

Daily nutritional support for a comfortable back and topline—helpful for horses in regular work, under saddle, or simply getting older.

Healthy nerve function — dapple grey horse trotting freely through a misty morning pasture

Healthy nerve function

Lion’s Mane is the core of this formula, paired with five more functional mushrooms to support healthy nerve function and steady, coordinated movement.

Gut-first daily foundation — dark bay horse resting comfortably on straw bedding

Gut-first daily foundation

Bovine colostrum, 3 billion CFU of probiotics, and prebiotics support digestion and nutrient absorption, so the rest of the formula has a solid base to work from.

Why Spine & Nerve for horse spine and nerve support

Built around Lion’s Mane, backed by 1,200+ owner reviews

We start with ImmuBiome Spine & Nerve because it’s formulated specifically for spine and nerve support. Lion’s Mane (Hericium erinaceus) sits at its core, with King Trumpet, Reishi, Antrodia, and two Cordyceps species, plus bovine colostrum, probiotics, and prebiotics for everyday gut health.

Want more Lion’s Mane? Nerve Boost is a companion formula with organic Lion’s Mane mycelium and fruiting body, beta-glucans, and prebiotics, designed to be fed alongside Spine & Nerve.

Follow the directions on the product label and use either one as part of a forage-based diet, turnout, consistent work, and your veterinarian’s wellness plan. These supplements do not replace veterinary care. If your horse shows any change in gait, coordination, or comfort, call your veterinarian first.

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Why horse owners choose ImmuBiome

Trusted by riders every day

Owner-trusted

Spine & Nerve averages 4.91★ across 1,200+ owner reviews

Equine-focused

Formulas designed around the horse microbiome

Ships from Idaho

UPS from Eden · free shipping on US subscriptions

30-day returns

Hassle-free returns if it is not the right fit

Spine & nerve support FAQ

Clear answers for horse owners
Does ImmuBiome replace veterinary care?
Who is this a good fit for?
Why feature Spine & Nerve first?
When does it make sense to add Nerve Boost?
How is this different from the Bone hub?
How much should I feed?
How do I get started?

Spine & Nerve reviews from horse owners

Real feedback on comfort, movement, and everyday wellbeing
HorseProductNerveEpmSpineSupplementImmubiomeProductsStuffLedoux
  • 5 stars: 1165 (92%)
  • 4 stars: 89 (7%)
  • 3 stars: 12 (1%)
  • 2 stars: 2 (0%)
  • 1 star: 0 (0%)
A
Alison K. (United States)
What is your horses estimated workload?: Heavy
What is your horses discipline?: Hunter Jumper
What is your horses age?: 8 to 12
Great Product!

My young hunter had 2 foraminotomy surgeries in the last 12 months and has been on the Spine & Nerve product to help his recovery. He is doing great on it! He's back to 100% and showing again. I truly believe it helped speed up his healing. I highly recommend this supplement for neuro issues.

m
molly g. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 21+
I definitely see a difference in my horses

I definitely see a difference in my horses comfort level- he is usually a picky eater but has eaten this no problem, I do wet the feed down

S
Suzanne G.
What is your horses estimated workload?: Medium
What is your horses discipline?: Dressage
What is your horses age?: 8 to 12
Spine & Nerve works!

Spine & Nerve has really made a difference for my horse coming back from EPM. His nervous system is more even keeled, his proprioception has improved, and overall I am so pleased we finally tried this product!

A
Anonymous (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 13 to 20
We have been using on our ex big time QH show

We have been using on our ex big time QH show horse who was ridden way to much. He is now one of our best special needs horses. He is doing well on this supplement.

D
DEB C. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 21+
Spine and Nerve for the win....again!

My senior horse came down with EPM again! He is now 27 and was worse than 5 years ago! I know that using Spine and Nerve has helped in his recovery again! He is doing great now! THANK YOU for the quality product for his recovery!

R
Rachel H. (United States)
What is your horses estimated workload?: Medium
What is your horses discipline?: Show Jumper
What is your horses age?: 4 to 7
We love our immubiome products!

We love all of our Immubiome products. Spine and Nerve helps every day to support my mare in her training and show adventures.

D
Diane &.A. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 13 to 20
This helped my horse w Lymes & Cushings

This helped my horse when he had Lymes disease, which we caught early but caused falling to the knees and bad muscle atrophy. Now he has tested positive for cushings/PPID, he has sadly lost energy after taking the cushings pills but he was super energetic and playful before and physically looks great, at 20! I body clip him and he has filled out beautifully.

A
Anonymous (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Hunter Jumper
What is your horses age?: 1 to 3
ImmunBiome gives you choices to treat your horses for their different needs.

ImmuBiome gives you choices to treat your horses for their different needs. I use Spine & Nerve for epm, Breathe for my colt who had pneumonia, Lean Muscle for my rehab project, and Immune for my mare fighting infection. It's great to have these natural products to help my horses. I fully believe in the power of mushrooms. I take them myself!

S
Sonja E. (United States)
What is your horses estimated workload?: Medium
What is your horses discipline?: Other
What is your horses age?: 13 to 20
This has been a good quality product for my horse

This has been a good quality product for my horse with polyneuritis. I also have him on the Nerve Booster.

A
Anonymous (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 1 to 3
Our two-year old gelding was diagnosed with EPM

Our two-year old gelding was diagnosed with EPM. I didn't want to just rely on his prescription. I happened across your product. The quality ingredients appealed to me. He unfortunately didn't have his weekly prescription available for two weeks. I started supplementing his feed with Spine and Nerve at the recommended dosage. I noticed a tremendous difference within those two weeks. I am so impressed with your product. I see no signs of him having EPM after two months of using Spine and Nerve. I continue to supplement his feed along with our other two horses.

A
Anonymous (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 13 to 20
EPM relapses are now gone

My mare suffered from EPM, two winters in a row. She has been on Spine and Nerve and doing very well. Love this product.

R
ROSANNE B. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Other
What is your horses age?: 21+
EPM has improved

its been 3 months now my 36 yr old has been on the spine and nerve.
She has improved but not perfect. She appears to be getting stronger every week. I plan on keeping her on this for awhile because of her age.
I know it will take time after getting the EPM

W
Wendy a.I. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Western
What is your horses age?: 21+
32 year-old quarter horse with EPM

I have a 32 year-old quarter horse that was diagnosed with EPM two years ago. He was failing and I thought it was the end of his life, but I was referred to Immubiome nerve boost products by my Equine nutritionist and he is thriving after two years.

Thank you so much, Dr Martha Faraday for your recommendation and for Immubiome for the products that are helping my horse live longer into his later years of life.

C
Cheryl W.
What is your horses estimated workload?: Medium
What is your horses discipline?: Other
What is your horses age?: 1 to 3
Love this product!! My horse recovering from EPM

Love this product!! My horse recovering from EPM has done wonders with him. Reordering to keep him on it for now.

P
Pamke526 (United States)
What is your horses estimated workload?: Medium
What is your horses discipline?: Racing
What is your horses age?: 13 to 20
We love Immubiome Spine & Nerve!

We give both of our horses Immubiome Spine & Nerve. We’ve been feeding it for about a month now and I can really tell the difference in how they move, how they look and their attitudes.
We will always use this for our two horses. ❤️❤️

T
Tina D. (United States)
What is your horses estimated workload?: Medium
What is your horses discipline?: Other
What is your horses age?: 21+
Highly recommend this supplement!!

My 21 yr old (EPM) horse, Iron, has been on this supplement for 2 months & I can tell he has improved. I highly recommend it!!

M
Michelle G. (United States)
What is your horses estimated workload?: Light
What is your horses discipline?: Western
What is your horses age?: 13 to 20
Test results speak for themselves:

Huge Thank you to: Dr Shannon DeArmas @https://haymarketvet.com for first testing LeDoux and putting him on Minocycline,
& Dr Anne-marie Hancock @https://truenorthequinevet.com for all of LeDoux's Osteopath adjustments and for sending us the information for https://www.immubiome.com works amazing & for highly recommending us to the one and only amazing Michelle Werner with https://www.bigstrideshoofcare.com for fixing Lyric & Rumors , LeDoux's hoofs amazing work, she truly loves what she does and our horses truly love her shes patient lyric went through 4 different farriers until Michelle Werner she has a very kind soul she is understanding, patient thanks so much for everything you do, Lyric is active and running laps she looks very fit now helps when you have an amazing farrier . Lyric is a totally different horse with her feet she picks them up without even being tied. ❤ huge thank you to EACH AND EVERYONE OF YOU!!!
This product is what has helped LeDoux's chronic lyme disease, the numbers speak for themselves:
LeDoux's Lyme from last year! has gone from:
November 2024 his first test
OSPF: 11,668
OSPA: 1061 Equivocal
OSPC: 68 Negative
OSPF: 4332 Positive
Now: ❤
OSPA: 523 Negative
OSPC: 88 Negative
OSPF: 2238 Positive
I wish i was promoting this product and making $ but i'm not just an honest opinion ❤ We will see the results once we put Rumor on this also her numbers are high! high 9,000 Plus

A
Anonymous (United States)
What is your horses estimated workload?: Medium
What is your horses discipline?: Hunter Jumper
What is your horses age?: 4 to 7
Helps an EPM Horse

I have a young horse recovering from EPM. Immubiome has definitely helped accelerate his recovery, in conjunction with a muscle builder and vet directed rehab plan.

M
Molly T.

I am currently treating for EPM, can I give while treating?

Vicki M.

Yes. I am finishing treatment for EPM and started my gelding Nerve and Spine as well as Nerve Boost as they were highly recommended when starting treatment. They seem to work well together.

See all Spine & Nerve reviews

Ready for everyday spine & nerve support?

Start with Spine & Nerve—or pair it with Nerve Boost for extra Lion’s Mane in the daily routine.

Shop Spine & Nerve

Shop Spine & Nerve

Everyday back and nerve support

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