Leaky Gut, also known as increased intestinal permeability, is a condition in which pathogens, toxins, dietary antigens and other unwanted substances ‘leak’ through the intestinal wall. By acting as a barrier between the internal environment (the body) and the external environment (lumen of the intestine), the intestinal epithelium plays an important role in protecting a horse’s body from harmful substances. Specialized proteins called tight junctions link intestinal epithelial cells together and selectively allow water and nutrients to pass through while blocking the passage of harmful substances, ultimately controlling which substances enter the bloodstream to be transported to internal organs. When tight junctions of the intestinal wall are compromised, the gut becomes more permeable, allowing pathogens and other undesirable substances to pass from the gut into the bloodstream. This condition is referred to as Leaky Gut Syndrome or simply ‘Leaky Gut’ and may be further characterized by widespread inflammation, poor nutrient absorption and in many cases autoimmune conditions.
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